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Translating Cutting-Edge Research into Real World Solutions. 

Molecular Trait Evolution offers innovation in the use of non-model microbes for new biocatalysts and renewable products.

Business Name

Microbial Strain

Enhancement & Optimization

Molecular Trait Evolution (MTE) is a biotechnology company that specializes in microbial strain enhancement and optimization. MTE designs natural or synthetic microbes or microbial consortia to solve complex biological problems. Worldwide the agricultural industry produces an estimated 182 billion tons of unusable plant waste every year. Our flagship product, Extremase, is a proprietary enzyme cocktail that converts non-food plant waste to sugar for ethanol fermentation and biorefining. Our technology has potential to fortify the US as the world’s leader in fuel ethanol production and open the biotech industry to use alternative feedstocks for biorefining while simultaneously reducing agricultural waste.

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Extremase

EXTREMASE is an enzyme cocktail that dissolves fiber, stalks, and shells for sugar fermentation and oil release.

More From Less

  • A 100 million gallon per year ethanol plant can generate an estimated 1 million bonus gallons of cellulosic ethanol with the same amount of corn

  • Increases food, fuel, and farm security due to increased production output with the same feedstock demands

  • Improves the performance of biomass to attain a sustainable bioeconomy

Faster Than The Competition

  • Max efficiency after 2 hours of incubation

  • Reduction in energy usage at the ethanol facility, resulting in continuous renewable energy at these locations

Enzymes with Endurance

  • Survives distillation and can be reused in closed systems

  • Circularity and reduction in waste are the core of the bioeconomy

  • Total ROI for the plant is improved since Extremase is reused rather than purchasing new enzymes

Applications

Water

It costs a small town hundreds of thousands of dollars annually to clean wastewater or risk even higher EPA fines and people’s health. Wastewater that is unfit to drink or discharge to waterways must be treated by a series of microbial processes culminating in anaerobic digestion. MTE provides solutions for increasing the rate of anaerobic digestion, the yield of biogas, and for co-production of high-value renewable hydrocarbons so that even small communities can see a revenue return instead of a taxpayer cost for efficiently cleaning wastewater.

Energy

Using the universal concepts of thermodynamics, enzyme kinetics, and metabolism we can coax living organisms to perform better and more efficiently than they do in nature. MTE provides solutions for using microbes to produce fuel from CO2 and renewable carbon feedstocks, such as excess sugar from corn or other non-food crops, wood, or waste biomass.

Designed Systems

Microbes naturally exist in complex communities, or mixtures. MTE has expertise in encouraging synergistic behaviors in robust natural microbial communities, as well as in designing communities to achieve desired biosynthetic capabilities.

Enzyme Technology

MTE has technology for creating new and better enzymes based on strategies using selection, and directed or designed modifications. These include ExtremaseTM cocktails for feedstock conversion to accelerate ethanol, biogas, and biohydrogen synthesis, and enzymes that promote metabolic balancing in evolved and engineered cell lines.

Why These Projects?

Current biotech solutions are overly reliant on “model organisms” and fail to employ the breadth of biological tools possible to optimize production. Our expertise in exotic biology means we can find the right tool for complex biotech problems. MTE is composed of experts in the study of exotic organisms which thrive at the limits of life under conditions that mimic biofuel processing. Generating biofuels and renewable chemicals from agricultural waste requires intense heat and acid to be converted into usable sugars for fermentation. We use enzymes from organisms which thrive in hot acid to develop an inexpensive acid and thermostable enzyme cocktail to digest lignocellulose for biorefineries. The cellulase enzyme market is estimated to be an approximately four-billion-dollar market and is expected to grow 7.5% annually through 2035. The primary end-users are processors of agricultural biomass and paper materials, though there is a growing market developing in the bioconversion of waste biomass into value-added products.

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Upgrading Value of Agriculture Wastes

As demand for agricultural products increases, so does the amount of unused, residual biomass which will be generated. The US is estimated to produce 450 million tons of biomass annually by 2030. By using ag biomass for biofuels and biorefining we gain three major benefits:

1. Economic Benefits

Biomass is less expensive than high value crops and does not compete with foodstuffs. Additionally, biofuels and biorefining plants create new jobs in rural areas and support nearby agricultural business.

2. Promotes a Circular Bioeconomy in Nebraska

Using ag biomass reduces the overall carbon footprint of the farmers and processors. Biomass is a renewable resource.

3. Potential for Value-Added Co-Products

Biorefining from ag biomass can crease additional value products from the biomass alongside biofuels, such as renewable plastics, pharmaceutical precursors, and biochar for soil improvement. 

Meet the MTE Team

60+ Years of Experience in Microbial Engineering

Sean Carr, PhD
President and CEO

  • EBRC Member

  • Member of Combine Ag Tech Incubator

  • Inaugural member of Coach N' Group

  • Post-Doctoral Research Associate at UNL

Nicole Buan, PhD
Co-Founder

  • EBRC Council Member

  • Editor, AEM and Frontiers

  • Professor of Biochemistry at the University of Nebraska – Lincoln

Paul Blum, PhD
Co-Founder

  • CEO of Neurocarrus

  • Member of IndieBio Cohort 6

  • Professor of Microbiology

  • University of California SC

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Contact us

Contact Us

mte@mtebiotech.com

© 2035 by MTE Molecular Trait Evolution

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